Fly into Fiumicino - Leonardo da Vinci Intl. Airport (FCO), the closest airport, located 5.3 mi (8.5 km) from the city center. If you can't find a flight that works for your travel itinerary, you could also fly into Ciampino Airport (CIA), which is 12.7 mi (20.4 km) away.
If you're traveling by train, make your way to Ponte Galeria Station or Fiera di Roma Station and explore the city from there.